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Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis

Received: 25 May 2019     Accepted: 20 June 2019     Published: 2 July 2019
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Abstract

Cirrhosis of liver is characterized by the replacement of normal liver tissue by scar tissue. The Child-Turcotte-Pugh (CTP) score is used to assess the prognosis of cirrhosis and included five factors: total bilirubin level, serum albumin, prothrombin time, ascites and hepatic encephalopathy. CTP score depends on clinical assessment which may result variation in scoring. Recently a new score is introduced, Albumin-Bilirubin (ALBI) score which may be done instead of CTP scoring in cirrhotic patient. This cross sectional study was conducted at the Department of Laboratory Medicine in collaboration with the Department of Hepatology, BSMMU, Dhaka, from March 2018 to February 2019. Blood samples were assayed from eighty one diagnosed cirrhotic patients. For all statistical analysis SPSS version 22 was used. The mean age of the study group was 46.1±16.0 years. 64.2% were male and 35.8% were female. Kappa (k) value was 0.759 between ALBI and CTP score. Pearson's correlation coefficient (r) test showed significant strong positive correlation between CTP score and ALBI score (r=+0.853, p<0.001). This study concluded that the ALBI score may be done alternative to the CTP score in cirrhotic patient because it’s simple, two parameters only, more evidence based and more objective.

Published in American Journal of Laboratory Medicine (Volume 4, Issue 3)
DOI 10.11648/j.ajlm.20190403.12
Page(s) 60-64
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Cirrhosis of Liver, Child-Turcotte-Pugh Score, Albumin-Bilirubin Score

References
[1] Kamath PS, Shah, VH. Overview of Cirrhosis, Sleisenger and Fordtran‘s Gastrointestinal and Liver Disease, Pathophysiology, Diagnosis, Management. 10th ed, 1976; 1254-1260.
[2] McCormick PA. Hepatic Cirrhosis, Sherlock’s Diseases of the Liver and Biliary System. 12th ed, 2011; 103-118.
[3] World Health Organization. HepatitisB. 2018. (https://www.who.int/news-room/fact-sheets/detail/hepatitis-b). n
[4] Alam S, Azam G, Mustafa G, Alam M, Ahmad N. Past, present, and future of hepatitis B and fatty liver in Bangladesh. Gastroenterol Hepatol Open Access. 2017; 6 (3): 197.
[5] Afroz S, Mahtab MA, Rahman S, Khan M. Hepatitis B virus is the leading cause of cirrhosis of liver in Bangladesh. Hepatol Int. 2007; 1 (1): 120.
[6] Rahman S, Ahmed MF, Alam MJ. Distribution of liver disease in Bangladesh: a cross-country study. Euroasian journal of hepato-gastroenterology. 2014; 4 (1): 25-30.
[7] Kalambokis G, Manousou P, Vibhakorn S, Marelli L, Cholongitas E, Senzolo M. Transjugular liver biopsy--indications, adequacy, quality of specimens, and complications- a systematic review. Journal of Hepatology. 2007; 47 (2): 284-294.
[8] Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL, O'Beirne J, Fox R, Skowronska A, Palmer D, Yeo W. Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach—the ALBI grade. Journal of Clinical Oncology. 2015; 33 (6): 550-558.
[9] Infante-Rivard C, Esnaola S, Villeneuve JP. Clinical and statistical validity of conventional prognostic factors in predicting short-term survival among cirrhotics. Hepatology. 1987; 7 (4): 660-4.
[10] Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973; 60: 646-9.
[11] Arroyo V. Pathophysiology, diagnosis and treatment of ascites in cirrhosis. Annals of hepatology. 2002; 1 (2): 72-9.
[12] Chan AW, Chan RC, Wong GL, et al. Evaluation of histological staging systems for primary biliary cirrhosis: correlation with clinical and biochemical factors and significance of pathological parameters in prognostication. Histopathology. 2014; 65: 174-86.
[13] Chen RC, Cai YJ, Wu JM, Wang XD, Song M, Wang YQ, Zheng MH, Chen YP, Lin Z, Shi KQ. Usefulness of albumin-bilirubin grade for evaluation of long-term prognosis for hepatitis B-related cirrhosis. Journal of viral hepatitis. 2017; 24 (3): 238-45.
[14] Peng Y, Qi X, Tang S, Deng H, Li J, Ning Z, Dai J, Hou F, Zhao J, Wang R, Guo X. Child-Pugh, MELD, and ALBI scores for predicting the in-hospital mortality in cirrhotic patients with acute-on-chronic liver failure. Expert review of gastroenterology & hepatology. 2016; 10 (8): 971-80.
[15] Zou D, Qi X, Zhu C, Ning Z, Hou F, Zhao J, Peng Y, Li J, Deng H, Guo X. Albumin-bilirubin score for predicting the in-hospital mortality of acute upper gastrointestinal bleeding in liver cirrhosis: A retrospective study. Turk J Gastroenterol. 2016 Mar 1; 27 (2): 180-86.
[16] Walker SW. Laboratory reference ranges. Davidson’s Principles Practice of Medicine, 21st ed, 2010; 1293-1298.
[17] Cholongitas E, Papatheodoridis GV, Vangeli M, Terreni N, Patch D, Burroughs AK. Systematic review: the model for end-stage liver disease–should it replace Child-Pugh's classification for assessing prognosis in cirrhosis?. Alimentary pharmacology & therapeutics. 2005; 22 (11-12): 1079-89.
[18] Lei Q, Zhang Y, Ke C, Yan C, Huang P, Shen H, Lei H, Chen Y, Luo J, Meng Z. Value of the albumin bilirubin score in the evaluation of hepatitis B virus related acute on chronic liver failure, liver cirrhosis, and hepatocellular carcinoma. Experimental and therapeutic medicine. 2018; 15 (3): 3074-9.
[19] Das DC, Al Mahtab M, Rahim MA, Malakar D, Kabir A, Rahman S. Hepatitis B virus remains the leading cause of cirrhosis of liver in Bangladesh. Bangladesh Medical Journal. 2016; 45 (3): 164-6.
[20] Xavier SA, Vilas-Boas R, Boal Carvalho P, Magalhães JT, Marinho CM, Cotter JB. Assessment of prognostic performance of Albumin–Bilirubin, Child–Pugh, and Model for End-stage Liver Disease scores in patients with liver cirrhosis complicated with acute upper gastrointestinal bleeding. European journal of gastroenterology & hepatology. 2018; 30 (6):652-8.
[21] Khalid SK, Garcia-Tsao G, Sanyal AJ, Shah V. Ascites. Clinical features, diagnosis and natural history. Portal Hypertension. 2005: 285-99.
[22] Morgan, M. Y. Hepatic Encephalopathy in patients with cirrhosis, Sherlock’s Diseases of the Liver and Biliary System. 12th ed, 2011; 121-151.
[23] Ogasawara S, Chiba T, Ooka Y, Suzuki E, Kanogawa N, Saito T, Motoyama T, Tawada A, Kanai F, Yokosuka O. Liver function assessment according to the Albumin–Bilirubin (ALBI) grade in sorafenib-treated patients with advanced hepatocellular carcinoma. Investigational new drugs. 2015; 33 (6): 1257-62.
[24] Lo CH, Liu MY, Lee MS, Yang JF, Jen YM, Lin CS, Chao HL, Shen PC, Huang WY. Comparison between Child-Turcotte-Pugh and albumin-bilirubin scores in assessing the prognosis of hepatocellular carcinoma after stereotactic ablative radiation therapy. International Journal of Radiation Oncology* Biology* Physics. 2017; 99 (1): 145-52.
[25] Chan AW, Chan RC, Wong GL, Wong VW, Choi PC, Chan HL, To KF. New simple prognostic score for primary biliary cirrhosis: Albumin-bilirubin score. Journal of gastroenterology and hepatology. 2015; 30 (9): 1391-6.
[26] Chen B, Lin S. Albumin-bilirubin (ALBI) score at admission predicts possible outcomes in patients with acute-on-chronic liver failure. Medicine. 2017; 96 (24).
Cite This Article
  • APA Style

    Sabrina Shafiq, Mohammad Nuruzzaman Khan, Bipasha Majumder, Mohammad Shahinul Alam, Mohammad Saiful Islam, et al. (2019). Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis. American Journal of Laboratory Medicine, 4(3), 60-64. https://doi.org/10.11648/j.ajlm.20190403.12

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    ACS Style

    Sabrina Shafiq; Mohammad Nuruzzaman Khan; Bipasha Majumder; Mohammad Shahinul Alam; Mohammad Saiful Islam, et al. Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis. Am. J. Lab. Med. 2019, 4(3), 60-64. doi: 10.11648/j.ajlm.20190403.12

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    AMA Style

    Sabrina Shafiq, Mohammad Nuruzzaman Khan, Bipasha Majumder, Mohammad Shahinul Alam, Mohammad Saiful Islam, et al. Correlation of Albumin-Bilirubin (ALBI) Score with Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis. Am J Lab Med. 2019;4(3):60-64. doi: 10.11648/j.ajlm.20190403.12

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  • @article{10.11648/j.ajlm.20190403.12,
      author = {Sabrina Shafiq and Mohammad Nuruzzaman Khan and Bipasha Majumder and Mohammad Shahinul Alam and Mohammad Saiful Islam and Tuhin Sultana},
      title = {Correlation of Albumin-Bilirubin (ALBI) Score with  Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis},
      journal = {American Journal of Laboratory Medicine},
      volume = {4},
      number = {3},
      pages = {60-64},
      doi = {10.11648/j.ajlm.20190403.12},
      url = {https://doi.org/10.11648/j.ajlm.20190403.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190403.12},
      abstract = {Cirrhosis of liver is characterized by the replacement of normal liver tissue by scar tissue. The Child-Turcotte-Pugh (CTP) score is used to assess the prognosis of cirrhosis and included five factors: total bilirubin level, serum albumin, prothrombin time, ascites and hepatic encephalopathy. CTP score depends on clinical assessment which may result variation in scoring. Recently a new score is introduced, Albumin-Bilirubin (ALBI) score which may be done instead of CTP scoring in cirrhotic patient. This cross sectional study was conducted at the Department of Laboratory Medicine in collaboration with the Department of Hepatology, BSMMU, Dhaka, from March 2018 to February 2019. Blood samples were assayed from eighty one diagnosed cirrhotic patients. For all statistical analysis SPSS version 22 was used. The mean age of the study group was 46.1±16.0 years. 64.2% were male and 35.8% were female. Kappa (k) value was 0.759 between ALBI and CTP score. Pearson's correlation coefficient (r) test showed significant strong positive correlation between CTP score and ALBI score (r=+0.853, p<0.001). This study concluded that the ALBI score may be done alternative to the CTP score in cirrhotic patient because it’s simple, two parameters only, more evidence based and more objective.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Correlation of Albumin-Bilirubin (ALBI) Score with  Child-Turcotte-Pugh (CTP) Score in the Evaluation of Liver Cirrhosis
    AU  - Sabrina Shafiq
    AU  - Mohammad Nuruzzaman Khan
    AU  - Bipasha Majumder
    AU  - Mohammad Shahinul Alam
    AU  - Mohammad Saiful Islam
    AU  - Tuhin Sultana
    Y1  - 2019/07/02
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajlm.20190403.12
    DO  - 10.11648/j.ajlm.20190403.12
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 60
    EP  - 64
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20190403.12
    AB  - Cirrhosis of liver is characterized by the replacement of normal liver tissue by scar tissue. The Child-Turcotte-Pugh (CTP) score is used to assess the prognosis of cirrhosis and included five factors: total bilirubin level, serum albumin, prothrombin time, ascites and hepatic encephalopathy. CTP score depends on clinical assessment which may result variation in scoring. Recently a new score is introduced, Albumin-Bilirubin (ALBI) score which may be done instead of CTP scoring in cirrhotic patient. This cross sectional study was conducted at the Department of Laboratory Medicine in collaboration with the Department of Hepatology, BSMMU, Dhaka, from March 2018 to February 2019. Blood samples were assayed from eighty one diagnosed cirrhotic patients. For all statistical analysis SPSS version 22 was used. The mean age of the study group was 46.1±16.0 years. 64.2% were male and 35.8% were female. Kappa (k) value was 0.759 between ALBI and CTP score. Pearson's correlation coefficient (r) test showed significant strong positive correlation between CTP score and ALBI score (r=+0.853, p<0.001). This study concluded that the ALBI score may be done alternative to the CTP score in cirrhotic patient because it’s simple, two parameters only, more evidence based and more objective.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

  • Department of Neurosurgery, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh

  • Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

  • Department of Hepatology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

  • Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

  • Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh

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