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Serum Vitamin D Level Status by Prostate Cancer Grade and Stage Among Native Africans

Received: 19 December 2021     Accepted: 5 January 2022     Published: 15 January 2022
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Abstract

Background: Vitamin D deficiency is widely speculated to be associated with prostate cancer (PCa) incidence, progression, aggressiveness, and metastatic potentials. However, evidence of this is limited among the black population. Hence, this study was spurred by the dearth of data in this regard. Methods: This was a prospectively designed/executed case-controlled descriptive study carried out in the University of Port Harcourt Teaching Hospital (UPTH) in the Niger Delta sub-region of Nigeria. Serum Vitamin D level status was determined/compared between the 380 histologically-verified positive PCa cases and the smoking/sex-matched 380 histologically-verified negative controls using descriptive and comparative statistical tools. The relationship/association between PCa grade/stage and Vitamin D level status was ascertained using crude and adjusted regression models. Data were managed and analyzed with the Statistical Package for Social Sciences version 23 and a p-value of <0.05 was deemed statistically significant. Results: The histologically-verified positive PCa patients had significantly lower mean Vitamin D level status (PCa patients: 24.55 ± 3.47 vs. controls: 49.73 ± 4.08; p<0.001) but higher mean prostate volumes, BMI status, plasma intact PTH levels, and total PSA levels compared to the histologically-verified negative controls. A decreasing trend of serum Vitamin level status was observed with worsening/increasing PCa grade and stage (p<0.05) among the biopsy positive PCa cases. An inverse relationship existed between Vitamin D level status and PCa grade/stage among the Vitamin D deficient PCa subgroup (p<0.05) but not the sufficient/insufficient PCa subgroups (p>0.05). Among the Vitamin D deficient PCa patients, this inverse relationship continued to strengthen with worsening PCa grade/stage. When compared with the PCa patients with the lowest PCa grade (ISUP grade 1) and stage (T1), an increased likelihood of Vitamin D deficiency was significantly associated with worsening PCa grade (ISUP 2 to 5) and stage (T2 to T4) on crude multiple logistic regression model which was subsequently amplified following adjusting for observed confounders. Conclusion: The study findings corroborate the epidemiologic evidence of the association of Vitamin D deficiency with PCa grade and stage; factors that define PCa aggressiveness and metastatic potentials. However, more robust studies among populations of the black race are highly recommended to validate conclusions from this current study.

Published in American Journal of Laboratory Medicine (Volume 7, Issue 1)
DOI 10.11648/j.ajlm.20220701.12
Page(s) 6-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Prostate Cancer, Vitamin D, Vitamin D Deficiency, Vitamin D Insufficiency

References
[1] Taitt HE. Global trends and prostate cancer: a review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location. Am J Men's Health. 2018; 12 (6): 1807-23.
[2] Rawla P. Epidemiology of prostate cancer. World J Oncol. 2019; 10 (2): 63.
[3] Dasgupta P, Baade PD, Aitken JF, Ralph N, Chambers SK, Dunn J. Geographical variations in prostate cancer outcomes: a systematic review of international evidence. Frontiers Oncol. 20198; 9: 238.
[4] Ukoli F, Osime U, Akereyeni F, Okunzuwa O, Kittles R, Adams-Campbell L. Prevalence of elevated serum prostate-specific antigen in rural Nigeria. Int J Urol. 2003; 10: 315–22.
[5] Abib A, Jaffar G, Khalid MS, Hussain Z, Zainab SW, Ashraf Z, Haroon A, Javed R, Khalid B, Habib P. Risk Factors Associated with Prostate Cancer. J Drug Del Ther. 2021; 11 (2): 188-93.
[6] Grant WB. Review of recent advances in understanding the role of vitamin D in reducing cancer risk: breast, colorectal, prostate, and overall cancer. Anticancer Res. 2020; 40 (1): 491-9.
[7] Bikle DD. Vitamin D: Newer concepts of its metabolism and function at the basic and clinical level. J Endocr Soc. 2020; 4 (2): bvz038.
[8] Bikle D, Christakos S. New aspects of vitamin D metabolism and action—addressing the skin as source and target. Nat Rev Endocrinol. 2020; 16 (4): 234-52.
[9] Saponaro F, Saba A, Zucchi R. An update on vitamin D metabolism. Int J Mol Sci. 2020; 21 (18): 6573.
[10] Richards Z, Batai K, Farhat R, Shah E, Makowski A, Gann PH, Kittles R, Nonn L. Prostatic compensation of the vitamin D axis in African American men. JCI Insight. 2017; 2 (2): e91054. doi: 10.1172/jci.insight.91054.
[11] Wagner D, Trudel D, Van der Kwast T, Nonn L, Giangreco AA, Li D, et al. Randomized clinical trial of vitamin D3 doses on prostatic vitamin D metabolite levels and ki67 labeling in prostate cancer patients. J Clin Endocrinol Metab. 2013; 98 (4): 1498-507.
[12] McCray T, Pacheco JV, Loitz CC, Garcia J, Baumann B, Schlicht MJ, Valyi-Nagy K, Abern MR, Nonn L. Vitamin D sufficiency enhances differentiation of patient-derived prostate epithelial organoids. iScience. 2021; 24 (1): 101974.
[13] Ramakrishnan S, Steck SE, Arab L, Zhang H, Bensen JT, Fontham ET, Johnson CS, Mohler JL, Smith GJ, Su LJ, Woloszynska A. Association among plasma 1, 25 (OH) 2D, ratio of 1, 25 (OH) 2D to 25 (OH) D, and prostate cancer aggressiveness. The Prostate. 2019; 79 (10): 1117-24.
[14] Naing L, Winn T, Rusli BN. Practical issues in calculating the sample size for prevalence studies. Arch Orofac Sci. 2006; 1: 9–14.
[15] Jeong CW, Park HK, Hong SK, Byun SS, Lee HJ, Lee SE. Comparison of prostate volume measured by transrectal ultrasonography and MRI with the actual prostate volume measured after radical prostatectomy. Urol Int. 2008; 81: 179–185.
[16] IOM (Institute of Medicine) Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press; 2011.
[17] Epstein JI, Egevad L, Amin MB, et al. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System. Am J Surg Pathol 2016; 40: 244.
[18] Buoyounnouski MK, Choyke PL, Mckennedy JK, Sartor O, Sandler HM, Amin MB, et al. Prostate cancer-Major changes in the American Joint Committee on cancer eight edition cancer staging manual. Ca cancer J Clin. 2017; 67: 243 – 53.
[19] WHO. Physical Status: The Use and Interpretation of Anthropometry: Report of a World Health Organization (WHO) Expert Committee. Geneva, Switzerland: World Health Organization; 1995.
[20] Trump DL, Chadha MK, Sunga AY, Fakih MG, Ashraf U, Silliman CG, Hollis BW, Nesline MK, Tian L, Tan W, Johnson CS. Vitamin D deficiency and insufficiency among patients with prostate cancer. BJU Int. 2009; 104 (7): 909.
[21] Choo CS, Mamedov A, Chung M, Choo R, Kiss A, Danjoux C. Vitamin D insufficiency is common in patients with non-metastatic prostate cancer. Nutri Res. 2011; 31 (1): 21-6.
[22] Kristal AR, Till C, Song X, Tangen CM, Goodman PJ, Neuhauser ML, Schenk JM, et al. Plasma vitamin D and prostate cancer risk: results from the Selenium and Vitamin E Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev. 2014; 23 (8): 1494-504.
[23] Aytaç Ş, Tuncay T, Musab AK, Ahmet Ü, Çağlar Y, Ayhan V. Is Prostate Cancer Related to Low Vitamin D Level?. Bull Urooncol. 2019; 18: 113-6.
[24] Adedapo KS, Olusanyo TO, Takure AO. Dietary implication of high malondialdehyde, reduced vitamin D and total antioxidant status of prostate cancer subjects in Ibadan. Int J Biomed Res. 2015; 6: 661-68.
[25] Odhiambo AO, Kiarie GW, Ngugi MP, Joshi MD. Serum Vitamin D profile in black African men with prostate cancer at a tertiary referral facility in Sub-Sahara Africa. J Dent Med Sci. 2014; 30: 60-4.
[26] Murphy AB, Nyame Y, Martin IK, Catalona WJ, Hollowel CM, Nadler RB, et al. Vitamin D deficiency predicts prostate biopsy outcome. Clin Cancer Res. 2014; 20: 2289-99.
[27] Bowen DK, Jordan GA, Malers TJ, Kittles RA, Murphy AB. Vitamin D deficiency predicts adverse pathology at time of radical prostatectomy. J Urol. 2015; 193: e641.
[28] Özman O, Türegün FA, Şimşekoğlu MF, Aferin U, Demirdağ Ç. Association Between Prostate Biopsy Results and Serum Vitamin D Levels. Bull Urooncol. 2021; 20 (2): 83-6.
[29] Thederan I, Chandrasekar T, Tennstedt P, Knipper S, Kuehl L, Tilki D, et al. Circulating Vitamin D and Selenium Levels and Outcome in Prostate Cancer Patients: Lessons from the MARTINI-Lifestyle Cohort. Eur Urol Focus. 2021; 7 (5): 973-9.
[30] Fleet JC, DeSmet M, Johnson R, Li Y. Vitamin D and cancer: a review of molecular mechanisms. Biochem J. 2012; 441 (1): 61-76.
[31] Bhoora S, Punchoo R. Policing cancer: Vitamin d arrests the cell cycle. Int Mol Sci. 2020; 21 (23): 9296.
[32] Karlsson S, Cruz MA, Faresjö M, Khamou AP, Larsson D. Inhibition of CYP27B1 and CYP24 Increases the Anti-proliferative Effects of 25-Hydroxyvitamin D3 in LNCaP Cells. Anticancer Res. 202; 41 (10): 4733-40.
[33] Udristioiu A, Farmazon I, Cojocaru M. Preclinical Researches of Vitamin D Role in Preventing Malignant Diseased, a Systematic Review. Int J Surg: Oncology. 2021; 6 (1).
[34] El-Sharkawy A, Malki A. Vitamin D signaling in inflammation and cancer: Molecular mechanisms and therapeutic implications. Molecules. 2020; 25 (14): 3219.
[35] Negri M, Gentile A, de Angelis C, Montò T, Patalano R, Colao A, et al. Vitamin D-induced molecular mechanisms to potentiate cancer therapy and to reverse drug-resistance in cancer cells. Nutrients. 2020; 12 (6): 1798.
[36] Blajszczak CC, Nonn L. Vitamin D regulates prostate cell metabolism via genomic and non-genomic mitochondrial redox-dependent mechanisms. The Journal of steroid biochemistry and molecular biology. 2019; 195: 105484.
[37] McCray T, Pacheco JV, Loitz CC, Garcia J, Baumann B, Schlicht MJ, et al. Vitamin D sufficiency enhances differentiation of patient-derived prostate epithelial organoids. Iscience. 2021; 24 (1): 101974.
Cite This Article
  • APA Style

    Collins Amadi, Chituru Orluwene, Bright Amadi. (2022). Serum Vitamin D Level Status by Prostate Cancer Grade and Stage Among Native Africans. American Journal of Laboratory Medicine, 7(1), 6-15. https://doi.org/10.11648/j.ajlm.20220701.12

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    ACS Style

    Collins Amadi; Chituru Orluwene; Bright Amadi. Serum Vitamin D Level Status by Prostate Cancer Grade and Stage Among Native Africans. Am. J. Lab. Med. 2022, 7(1), 6-15. doi: 10.11648/j.ajlm.20220701.12

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    AMA Style

    Collins Amadi, Chituru Orluwene, Bright Amadi. Serum Vitamin D Level Status by Prostate Cancer Grade and Stage Among Native Africans. Am J Lab Med. 2022;7(1):6-15. doi: 10.11648/j.ajlm.20220701.12

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  • @article{10.11648/j.ajlm.20220701.12,
      author = {Collins Amadi and Chituru Orluwene and Bright Amadi},
      title = {Serum Vitamin D Level Status by Prostate Cancer Grade and Stage Among Native Africans},
      journal = {American Journal of Laboratory Medicine},
      volume = {7},
      number = {1},
      pages = {6-15},
      doi = {10.11648/j.ajlm.20220701.12},
      url = {https://doi.org/10.11648/j.ajlm.20220701.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20220701.12},
      abstract = {Background: Vitamin D deficiency is widely speculated to be associated with prostate cancer (PCa) incidence, progression, aggressiveness, and metastatic potentials. However, evidence of this is limited among the black population. Hence, this study was spurred by the dearth of data in this regard. Methods: This was a prospectively designed/executed case-controlled descriptive study carried out in the University of Port Harcourt Teaching Hospital (UPTH) in the Niger Delta sub-region of Nigeria. Serum Vitamin D level status was determined/compared between the 380 histologically-verified positive PCa cases and the smoking/sex-matched 380 histologically-verified negative controls using descriptive and comparative statistical tools. The relationship/association between PCa grade/stage and Vitamin D level status was ascertained using crude and adjusted regression models. Data were managed and analyzed with the Statistical Package for Social Sciences version 23 and a p-value of Results: The histologically-verified positive PCa patients had significantly lower mean Vitamin D level status (PCa patients: 24.55 ± 3.47 vs. controls: 49.73 ± 4.08; p0.05). Among the Vitamin D deficient PCa patients, this inverse relationship continued to strengthen with worsening PCa grade/stage. When compared with the PCa patients with the lowest PCa grade (ISUP grade 1) and stage (T1), an increased likelihood of Vitamin D deficiency was significantly associated with worsening PCa grade (ISUP 2 to 5) and stage (T2 to T4) on crude multiple logistic regression model which was subsequently amplified following adjusting for observed confounders. Conclusion: The study findings corroborate the epidemiologic evidence of the association of Vitamin D deficiency with PCa grade and stage; factors that define PCa aggressiveness and metastatic potentials. However, more robust studies among populations of the black race are highly recommended to validate conclusions from this current study.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Serum Vitamin D Level Status by Prostate Cancer Grade and Stage Among Native Africans
    AU  - Collins Amadi
    AU  - Chituru Orluwene
    AU  - Bright Amadi
    Y1  - 2022/01/15
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ajlm.20220701.12
    DO  - 10.11648/j.ajlm.20220701.12
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 6
    EP  - 15
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20220701.12
    AB  - Background: Vitamin D deficiency is widely speculated to be associated with prostate cancer (PCa) incidence, progression, aggressiveness, and metastatic potentials. However, evidence of this is limited among the black population. Hence, this study was spurred by the dearth of data in this regard. Methods: This was a prospectively designed/executed case-controlled descriptive study carried out in the University of Port Harcourt Teaching Hospital (UPTH) in the Niger Delta sub-region of Nigeria. Serum Vitamin D level status was determined/compared between the 380 histologically-verified positive PCa cases and the smoking/sex-matched 380 histologically-verified negative controls using descriptive and comparative statistical tools. The relationship/association between PCa grade/stage and Vitamin D level status was ascertained using crude and adjusted regression models. Data were managed and analyzed with the Statistical Package for Social Sciences version 23 and a p-value of Results: The histologically-verified positive PCa patients had significantly lower mean Vitamin D level status (PCa patients: 24.55 ± 3.47 vs. controls: 49.73 ± 4.08; p0.05). Among the Vitamin D deficient PCa patients, this inverse relationship continued to strengthen with worsening PCa grade/stage. When compared with the PCa patients with the lowest PCa grade (ISUP grade 1) and stage (T1), an increased likelihood of Vitamin D deficiency was significantly associated with worsening PCa grade (ISUP 2 to 5) and stage (T2 to T4) on crude multiple logistic regression model which was subsequently amplified following adjusting for observed confounders. Conclusion: The study findings corroborate the epidemiologic evidence of the association of Vitamin D deficiency with PCa grade and stage; factors that define PCa aggressiveness and metastatic potentials. However, more robust studies among populations of the black race are highly recommended to validate conclusions from this current study.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Department of Chemical Pathology, Rivers State University, Port Harcourt, Nigeria

  • Department of Chemical Pathology, Rivers State University, Port Harcourt, Nigeria

  • Department of Chemical Pathology, Rivers State University, Port Harcourt, Nigeria

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