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Community-Based Active Case Finding to Increase Tuberculosis Case Detection and Treatment Success Rate in High Tuberculosis Burden Areas of Arsi Zone, Oromia

Received: 5 October 2021     Accepted: 28 October 2021     Published: 7 December 2021
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Abstract

Background: More than 9 million new cases of tuberculosis (TB) occur per year and about two million people die of TB. The probable cause of death is delay in diagnosis, low case detection rate and treatment success rate. Due to the low potential of tuberculosis (TB) microscopic examination and the need to increase rate of new TB case identification is also increased. Objective: To determine magnitude of active tuberculosis cases, evaluate the performance of LED-FM and X-pert MTB/RIF assay and characterize treatment outcome Methods: The door-to-door survey for TB in high TB burden areas of Arsi zone was performed. The participants were screened based on typical TB symptoms. The sputum samples were collected and transported to the laboratories. Culture, LED-FM and X-pert MTB/RIF assay were performed to confirm tuberculosis infection. Result was communicated through cell phone or short message system (SMS) for issuing of positive results. The health extension worker would contact diagnosed patients referred to their local health center for care. Finally, the performance of diagnostic tests, case detection rate and treatment success were determined. Result: In this study 344 pulmonary TB suspected study participants were involved from the three study sites. Based on the LED microscope results the general prevalence of pulmonary TB among the current study participants was 2.3%. On the other hand Gene X-pert MTB/RIF assay could show that 9 (2.6%) of the study participants became positive for pulmonary TB cases. There was 1 (0.3%) discordant result between the two assay methods. LED microscope missed one TB suspected case which was detected by Gen X-pert MTB/RIF assay and then confirmed by LJ culture media and become positive for pulmonary TB. Hence, the overall prevalence of pulmonary TB in our current study became 2.6% with 95% CI (1.2-4.5) using LJ culture media as tiebreaker. Of 344 study participants in this study, 9 (2.6%) were positive for pulmonary TB and given first line anti-TB drugs. Of the nine pulmonary TB test positive study participants who had prescribed with first line anti-TB drugs in which 2 (22.2%) were known to be cured as well as 7 (77.8%) had completed the treatment regimen prescribed for them.

Published in American Journal of Laboratory Medicine (Volume 6, Issue 6)
DOI 10.11648/j.ajlm.20210606.13
Page(s) 91-100
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

MTB, Active Case Finding, Treatment Outcome

References
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    Merga Gonfa Bati, Bizuayehu Gurmessa Ejeta. (2021). Community-Based Active Case Finding to Increase Tuberculosis Case Detection and Treatment Success Rate in High Tuberculosis Burden Areas of Arsi Zone, Oromia. American Journal of Laboratory Medicine, 6(6), 91-100. https://doi.org/10.11648/j.ajlm.20210606.13

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    ACS Style

    Merga Gonfa Bati; Bizuayehu Gurmessa Ejeta. Community-Based Active Case Finding to Increase Tuberculosis Case Detection and Treatment Success Rate in High Tuberculosis Burden Areas of Arsi Zone, Oromia. Am. J. Lab. Med. 2021, 6(6), 91-100. doi: 10.11648/j.ajlm.20210606.13

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    AMA Style

    Merga Gonfa Bati, Bizuayehu Gurmessa Ejeta. Community-Based Active Case Finding to Increase Tuberculosis Case Detection and Treatment Success Rate in High Tuberculosis Burden Areas of Arsi Zone, Oromia. Am J Lab Med. 2021;6(6):91-100. doi: 10.11648/j.ajlm.20210606.13

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  • @article{10.11648/j.ajlm.20210606.13,
      author = {Merga Gonfa Bati and Bizuayehu Gurmessa Ejeta},
      title = {Community-Based Active Case Finding to Increase Tuberculosis Case Detection and Treatment Success Rate in High Tuberculosis Burden Areas of Arsi Zone, Oromia},
      journal = {American Journal of Laboratory Medicine},
      volume = {6},
      number = {6},
      pages = {91-100},
      doi = {10.11648/j.ajlm.20210606.13},
      url = {https://doi.org/10.11648/j.ajlm.20210606.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210606.13},
      abstract = {Background: More than 9 million new cases of tuberculosis (TB) occur per year and about two million people die of TB. The probable cause of death is delay in diagnosis, low case detection rate and treatment success rate. Due to the low potential of tuberculosis (TB) microscopic examination and the need to increase rate of new TB case identification is also increased. Objective: To determine magnitude of active tuberculosis cases, evaluate the performance of LED-FM and X-pert MTB/RIF assay and characterize treatment outcome Methods: The door-to-door survey for TB in high TB burden areas of Arsi zone was performed. The participants were screened based on typical TB symptoms. The sputum samples were collected and transported to the laboratories. Culture, LED-FM and X-pert MTB/RIF assay were performed to confirm tuberculosis infection. Result was communicated through cell phone or short message system (SMS) for issuing of positive results. The health extension worker would contact diagnosed patients referred to their local health center for care. Finally, the performance of diagnostic tests, case detection rate and treatment success were determined. Result: In this study 344 pulmonary TB suspected study participants were involved from the three study sites. Based on the LED microscope results the general prevalence of pulmonary TB among the current study participants was 2.3%. On the other hand Gene X-pert MTB/RIF assay could show that 9 (2.6%) of the study participants became positive for pulmonary TB cases. There was 1 (0.3%) discordant result between the two assay methods. LED microscope missed one TB suspected case which was detected by Gen X-pert MTB/RIF assay and then confirmed by LJ culture media and become positive for pulmonary TB. Hence, the overall prevalence of pulmonary TB in our current study became 2.6% with 95% CI (1.2-4.5) using LJ culture media as tiebreaker. Of 344 study participants in this study, 9 (2.6%) were positive for pulmonary TB and given first line anti-TB drugs. Of the nine pulmonary TB test positive study participants who had prescribed with first line anti-TB drugs in which 2 (22.2%) were known to be cured as well as 7 (77.8%) had completed the treatment regimen prescribed for them.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Community-Based Active Case Finding to Increase Tuberculosis Case Detection and Treatment Success Rate in High Tuberculosis Burden Areas of Arsi Zone, Oromia
    AU  - Merga Gonfa Bati
    AU  - Bizuayehu Gurmessa Ejeta
    Y1  - 2021/12/07
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajlm.20210606.13
    DO  - 10.11648/j.ajlm.20210606.13
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
    SP  - 91
    EP  - 100
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20210606.13
    AB  - Background: More than 9 million new cases of tuberculosis (TB) occur per year and about two million people die of TB. The probable cause of death is delay in diagnosis, low case detection rate and treatment success rate. Due to the low potential of tuberculosis (TB) microscopic examination and the need to increase rate of new TB case identification is also increased. Objective: To determine magnitude of active tuberculosis cases, evaluate the performance of LED-FM and X-pert MTB/RIF assay and characterize treatment outcome Methods: The door-to-door survey for TB in high TB burden areas of Arsi zone was performed. The participants were screened based on typical TB symptoms. The sputum samples were collected and transported to the laboratories. Culture, LED-FM and X-pert MTB/RIF assay were performed to confirm tuberculosis infection. Result was communicated through cell phone or short message system (SMS) for issuing of positive results. The health extension worker would contact diagnosed patients referred to their local health center for care. Finally, the performance of diagnostic tests, case detection rate and treatment success were determined. Result: In this study 344 pulmonary TB suspected study participants were involved from the three study sites. Based on the LED microscope results the general prevalence of pulmonary TB among the current study participants was 2.3%. On the other hand Gene X-pert MTB/RIF assay could show that 9 (2.6%) of the study participants became positive for pulmonary TB cases. There was 1 (0.3%) discordant result between the two assay methods. LED microscope missed one TB suspected case which was detected by Gen X-pert MTB/RIF assay and then confirmed by LJ culture media and become positive for pulmonary TB. Hence, the overall prevalence of pulmonary TB in our current study became 2.6% with 95% CI (1.2-4.5) using LJ culture media as tiebreaker. Of 344 study participants in this study, 9 (2.6%) were positive for pulmonary TB and given first line anti-TB drugs. Of the nine pulmonary TB test positive study participants who had prescribed with first line anti-TB drugs in which 2 (22.2%) were known to be cured as well as 7 (77.8%) had completed the treatment regimen prescribed for them.
    VL  - 6
    IS  - 6
    ER  - 

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Author Information
  • Department of Medical Laboratory Science, College of Health Science, Arsi University, Asella, Ethiopia

  • Department of Medical Laboratory Science, College of Health Science, Arsi University, Asella, Ethiopia

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