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Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases

Received: 31 July 2019     Accepted: 30 August 2019     Published: 19 September 2019
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Abstract

Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.

Published in American Journal of Laboratory Medicine (Volume 4, Issue 5)
DOI 10.11648/j.ajlm.20190405.11
Page(s) 79-86
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Thrombophilia Assessment, Protein C, Protein S, Antithrombin, Factor V mutation, Factor II Mutation

References
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Cite This Article
  • APA Style

    Ilham Karrati, Hanane Mouhib, Hicham Yahyaoui, Radia Amaddah, Mustapha Aitameur, et al. (2019). Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. American Journal of Laboratory Medicine, 4(5), 79-86. https://doi.org/10.11648/j.ajlm.20190405.11

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    ACS Style

    Ilham Karrati; Hanane Mouhib; Hicham Yahyaoui; Radia Amaddah; Mustapha Aitameur, et al. Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. Am. J. Lab. Med. 2019, 4(5), 79-86. doi: 10.11648/j.ajlm.20190405.11

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    AMA Style

    Ilham Karrati, Hanane Mouhib, Hicham Yahyaoui, Radia Amaddah, Mustapha Aitameur, et al. Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. Am J Lab Med. 2019;4(5):79-86. doi: 10.11648/j.ajlm.20190405.11

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  • @article{10.11648/j.ajlm.20190405.11,
      author = {Ilham Karrati and Hanane Mouhib and Hicham Yahyaoui and Radia Amaddah and Mustapha Aitameur and Mohamed Chakour},
      title = {Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases},
      journal = {American Journal of Laboratory Medicine},
      volume = {4},
      number = {5},
      pages = {79-86},
      doi = {10.11648/j.ajlm.20190405.11},
      url = {https://doi.org/10.11648/j.ajlm.20190405.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190405.11},
      abstract = {Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.},
     year = {2019}
    }
    

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    T1  - Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases
    AU  - Ilham Karrati
    AU  - Hanane Mouhib
    AU  - Hicham Yahyaoui
    AU  - Radia Amaddah
    AU  - Mustapha Aitameur
    AU  - Mohamed Chakour
    Y1  - 2019/09/19
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajlm.20190405.11
    DO  - 10.11648/j.ajlm.20190405.11
    T2  - American Journal of Laboratory Medicine
    JF  - American Journal of Laboratory Medicine
    JO  - American Journal of Laboratory Medicine
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    EP  - 86
    PB  - Science Publishing Group
    SN  - 2575-386X
    UR  - https://doi.org/10.11648/j.ajlm.20190405.11
    AB  - Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.
    VL  - 4
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    ER  - 

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Author Information
  • Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco

  • Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco

  • Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco

  • Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco

  • Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco

  • Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco

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