Olfactory Neuroblastoma Presenting as a Submandibular Mass

Sona Appukutty; Silvana Di Palma; Stephen Whitaker; Katie Wood

doi:doi:10.11648/j.ajlm.20190402.12

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Olfactory Neuroblastoma Presenting as a Submandibular Mass

Sona Appukutty, Silvana Di Palma, Stephen Whitaker, Katie Wood

Published in American Journal of Laboratory Medicine (Volume 4, Issue 2)

Received: 15 March 2019 Accepted: 22 April 2019 Published: 9 May 2019

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Abstract

Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.

Published in	American Journal of Laboratory Medicine (Volume 4, Issue 2)
DOI	10.11648/j.ajlm.20190402.12
Page(s)	35-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Olfactory Neuroblastoma, Metastasis, Submandibular Gland

References

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APA Style

Sona Appukutty, Silvana Di Palma, Stephen Whitaker, Katie Wood. (2019). Olfactory Neuroblastoma Presenting as a Submandibular Mass. American Journal of Laboratory Medicine, 4(2), 35-39. https://doi.org/10.11648/j.ajlm.20190402.12

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ACS Style

Sona Appukutty; Silvana Di Palma; Stephen Whitaker; Katie Wood. Olfactory Neuroblastoma Presenting as a Submandibular Mass. Am. J. Lab. Med. 2019, 4(2), 35-39. doi: 10.11648/j.ajlm.20190402.12

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AMA Style

Sona Appukutty, Silvana Di Palma, Stephen Whitaker, Katie Wood. Olfactory Neuroblastoma Presenting as a Submandibular Mass. Am J Lab Med. 2019;4(2):35-39. doi: 10.11648/j.ajlm.20190402.12

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@article{10.11648/j.ajlm.20190402.12,
  author = {Sona Appukutty and Silvana Di Palma and Stephen Whitaker and Katie Wood},
  title = {Olfactory Neuroblastoma Presenting as a Submandibular Mass},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {2},
  pages = {35-39},
  doi = {10.11648/j.ajlm.20190402.12},
  url = {https://doi.org/10.11648/j.ajlm.20190402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190402.12},
  abstract = {Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.},
 year = {2019}
}

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TY  - JOUR
T1  - Olfactory Neuroblastoma Presenting as a Submandibular Mass
AU  - Sona Appukutty
AU  - Silvana Di Palma
AU  - Stephen Whitaker
AU  - Katie Wood
Y1  - 2019/05/09
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190402.12
DO  - 10.11648/j.ajlm.20190402.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 35
EP  - 39
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190402.12
AB  - Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.
VL  - 4
IS  - 2
ER  -

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Author Information

Sona Appukutty

Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
Silvana Di Palma

Department of Histopathology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Stephen Whitaker

Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK
Katie Wood

Department of Oncology, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK

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Plain Text BibTeX RIS

APA Style

Sona Appukutty, Silvana Di Palma, Stephen Whitaker, Katie Wood. (2019). Olfactory Neuroblastoma Presenting as a Submandibular Mass. American Journal of Laboratory Medicine, 4(2), 35-39. https://doi.org/10.11648/j.ajlm.20190402.12

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ACS Style

Sona Appukutty; Silvana Di Palma; Stephen Whitaker; Katie Wood. Olfactory Neuroblastoma Presenting as a Submandibular Mass. Am. J. Lab. Med. 2019, 4(2), 35-39. doi: 10.11648/j.ajlm.20190402.12

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AMA Style

Sona Appukutty, Silvana Di Palma, Stephen Whitaker, Katie Wood. Olfactory Neuroblastoma Presenting as a Submandibular Mass. Am J Lab Med. 2019;4(2):35-39. doi: 10.11648/j.ajlm.20190402.12

Copy | Download

@article{10.11648/j.ajlm.20190402.12,
  author = {Sona Appukutty and Silvana Di Palma and Stephen Whitaker and Katie Wood},
  title = {Olfactory Neuroblastoma Presenting as a Submandibular Mass},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {2},
  pages = {35-39},
  doi = {10.11648/j.ajlm.20190402.12},
  url = {https://doi.org/10.11648/j.ajlm.20190402.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190402.12},
  abstract = {Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Olfactory Neuroblastoma Presenting as a Submandibular Mass
AU  - Sona Appukutty
AU  - Silvana Di Palma
AU  - Stephen Whitaker
AU  - Katie Wood
Y1  - 2019/05/09
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190402.12
DO  - 10.11648/j.ajlm.20190402.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 35
EP  - 39
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190402.12
AB  - Background: Olfactory Neuroblastoma is a rare, locally aggressive malignant neoplasm arising from the olfactory epithelium, which causes metastasis by lymphatic and haematogenous routes, with most common site being the cervical lymph nodes. Materials and Methods: Clinical history was retrieved from discussion in the Head and Neck multidisciplinary team meeting and medical records. Routine macroscopic and microscopic histological examination along with appropriate immunohistochemistry was performed. In addition, we include the review of literature of olfactory neuroblastoma metastatic to different sites. Results: A 75 year old female presented with a left submandibular mass which on biopsy was diagnosed as high grade neuroendocrine carcinoma requiring further investigation for characterising it as primary or metastatic. The histological diagnosis proved difficult and doubtful, till after five months when on follow up investigation a skull base lesion was identified, this on biopsy was confirmed to be an olfactory neuroblastoma. Conclusion: It is important to think laterally and consider metastatic tumours when evaluating neuroendocrine lesions in the submandibular region as this can be the first manifestation.
VL  - 4
IS  - 2
ER  -

Copy | Download